Christian-HinmanLab@Illinois
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in press
Hormone Changes in Epilepsy
Christian-Hinman CA, Harden CL
In Epilepsy: A Comprehensive Textbook, 3rd Edition, Engel Jr. J. and Moshé S.L. (editors-in-chief), Wolters Kluwer Health

2022
Increased GABA transmission to GnRH neurons after intrahippocampal kainic acid injection in mice is sex-specific and associated with estrous cycle disruption
Ingram RJ, Leverton LK, Daniels VC, Li J, Christian-Hinman CA
Neurobiol Dis, 172:105822
​
Epilepsy-associated increase in gonadotropin-releasing hormone neuron firing in diestrous female mice is independent of chronic seizure burden severity
Li J, Christian-Hinman CA
Epilepsy Res, 184:106948
​

Phenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice
Cutia CA, Leverton LK, Ge X,  Youssef R, Raetzman LT, Christian-Hinman CA
Exp Neurol, 335:114118

Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity
Walters JM, Kim EC, Zhang J, Jeong HG, Bajaj A, Baculis B, Tracy G, Ibrahim B, Christian-Hinman CA, Llano DA, Huesmann GR, Chung HJ
Epilepsia, 
63:1211-1224

2021
Spontaneous seizure and memory loss in mice expressing an epileptic encephalopathy variant in the calmodulin-binding domain of Kv7.2
Kim EC, Zhang J, Tang AY, Bolton EC, Rhodes JS, Christian-Hinman CA, Chung HJ 
Proc Natl Acad Sci USA, 118:e2021265118

From benzodiazepines to fatty acids: Revisiting the role of ACBP/DBI
Alquier T, Christian-Hinman CA, Alfonso J, Færgeman NJ
Trends Endocrinol Metab​, 32:890-903

Infantile spasms-linked Nedd4-2 mediates hippocampal plasticity and learning via cofilin signaling
Lee KY, Zhu J, Cutia CA, Christian-Hinman CA, Rhodes JS, Tsai NP
EMBO Reports, 22:e52645

Is On-Demand Dynorphin Destined to Be in Demand to Decrease Seizures?
Christian-Hinman CA
Epilepsy Curr, 21:48-50

2020
Simultaneous two-photon activation and imaging of neural activity based on spectral-temporal modulation of supercontinuum light
Liu YZ, Renteria C, Courtney CD, Ibrahim B, You S, Chaney EJ, Barkalifa R, Iyer RR, Zurauskas M, Tu H, Llano DA, Christian-Hinman CA, Boppart SA
Neurophotonics, 7:045007

Seizure burden fluctuates with the female reproductive cycle in a mouse model of chronic temporal lobe epilepsy
Li J, Leverton LK, Naganatanahalli LM, Christian-Hinman CA
Exp Neurol, 334:113492

Assessin' the Vexin' Connexin Between Severity of Epilepsy and Hippocampal Gliosis
Courtney CD, Christian-Hinman C
Epilepsy Curr, 20:294-296

Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies
Christian CA, Reddy DS, Maguire J, Forcelli PA
Pharmacol Rev, 72:767-800


Nucleus-specific modulation of phasic and tonic inhibition by endogenous neurosteroidogenesis in the murine thalamus
Christian CA
Synapse, 74:e22144
​

Show Me the Meaning of Being Lonely (and Its Effects on Seizure Burden and Comorbidities)
Lozano L, Christian CA
Epilepsy Curr, 20:48-50

A Single Test to Study Social Behavior and Repetitive Self-Grooming in Mice
Lawande NV*, Ujjainwala AL*, Christian CA ​(*equal contribution)
Bio Protoc, 10:e3499


2019
Estrous Cycle Monitoring in Mice with Rapid Data Visualization and Analysis
Pantier LK*, Li J*, Christian CA ​(*equal contribution)
Bio Protoc, 9:e3354

Inhibition Gets a New KAR Smell
Courtney CD, Christian CA
Epilepsy Curr, 19:187-189

Differential impacts on multiple forms of spatial and contextual memory in diazepam binding inhibitor knockout mice
​Ujjainwala AL*, Courtney CD*, Wojnowski NM, Rhodes JS, Christian CA ​(*equal contribution)
J Neurosci Res, 97:683-697

Changes in both neuron intrinsic properties and neurotransmission drive the increase in GnRH neuron firing rate during estradiol positive feedback
Adams CE, DeFazio RA,  Christian CA,  ​Milescu LS, Schnell S, Moenter SM 
J Neurosci, 39:2091-2101

2018
Dynamic and sex-specific changes in gonadotropin-releasing hormone neuron activity and excitability in a mouse model of temporal lobe epilepsy
Li J, Robare JA, Gao L, Ghane MA, Flaws JA, Nelson ME, Christian CA
eNeuro, 5:e0273-18.2018

Subregion-specific impacts of genetic loss of diazepam binding inhibitor on synaptic inhibition in the murine hippocampus
Courtney CD, Christian CA
Neuroscience, 388:128-138

Genetic loss of diazepam binding inhibitor in mice impairs social interest
​Ujjainwala AL, Courtney CD, Rhoads SG, Rhodes JS, Christian CA
Genes Brain Behav, 17:e12442
​
The Perils of Generalizing About GABA in Seizure Generalization
Christian CA

Epilepsy Curr, 18:113-114

Persistent Protection Against Pathology and Paroxysms by P2X7R Antagonism
Christian CA

Epilepsy Curr, 18:42-44

2017
Developmental Inflammation Takes a Toll: Early Immune Responses Increase Seizure Susceptibility via Astrocytic TLR4 Signaling
Sobieski C, Christian CA
Epilepsy Curr, 17:370-371

Mom Genes: A Role for Loss of Maternal Ube3a in GABAergic Neurons in Angelman Syndrome
Christian CA
Epilepsy Curr, 17:237-238

Regulation of thalamic and cortical network synchrony by Scn8a
Makinson CD, Tanaka BS, Sorokin JM, Wong JC, Christian CA, Goldin AL, Escayg A, Huguenard JR
Neuron, 93:1165-1179


Disrupted female estrous cyclicity in the intrahippocampal kainic acid mouse model of temporal lobe epilepsy
Li J, Kim JS, Abejuela VA, Lamano JB, Klein NJ, Christian CA
Epilepsia Open,​ 2:39-47

Neurophysiology of Gonadotropin-Releasing Hormone Neurons
Christian CA
In Hormones, Brain and Behavior, 3rd Edition, Pfaff, D.W. and Joëls, M. (editors-in-chief), Oxford: Academic Press. Vol. 3, pp. 379-400 


2016
A Nose for Seizures: A Potential Role for Olfaction in the Co-Morbidity of Depression and Epilepsy?
Christian CA
Epilepsy Curr, 16:256-257


Seizure Activity and Intervention Efficacy are Shaped by REMnants of Preceding Brain States
Christian CA
Epilepsy Curr, 16:164-165


Feedback modulation of neural network synchrony and seizure susceptibility by Mdm2-p53-Nedd4-2 signaling
Jewett KA, Christian CA, Bacos JT, Lee KY, Zhu J, Tsai NP
Mol Brain, 9:32
​

2013
Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling
Christian CA, Huguenard JR
Proc Natl Acad Sci USA, 110:20278-20283


Sniffer Patch Laser Uncaging REsponse (SPLURgE): an assay of regional differences in allosteric receptor modulation and neurotransmitter clearance
Christian CA, Huguenard JR
J Neurophysiol, 110:1722-1731


Endogenous positive allosteric modulation of GABA(A) receptors by Diazepam binding inhibitor
Christian CA, Herbert AG, Holt RL, Peng K, Sherwood KD, Pangratz-Fuehrer S, Rudolph U, Huguenard JR
Neuron, 78:1063-1074


2010
Focal cortical infarcts alter intrinsic excitability and synaptic excitation in the reticular thalamic nucleus
Paz JT, Christian CA, Parada I, Prince DA, Huguenard JR
J Neurosci, 30:5465-5479


The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges
Christian CA, Moenter SM
Endocr Rev, 31:544-577


2009
Neurobiological mechanisms underlying oestradiol negative and positive feedback regulation of gonadotrophin-releasing hormone neurones
Moenter SM, Chu Z, Christian CA
J Neuroendocrinol, 21:327-333


Estradiol suppresses glutamatergic transmission to gonadotropin-releasing hormone neurons in a model of negative feedback in mice
Christian CA, Pielecka-Fortuna J, Moenter SM
Biol Reprod, 80:1128-1135


2008
Critical roles for fast synaptic transmission in mediating estradiol negative and positive feedback in the neural control of ovulation
Christian CA, Moenter SM
Endocrinology, 149:5500-5508


Classical estrogen receptor alpha signaling mediates negative and positive feedback on gonadotropin-releasing hormone neuron firing
Christian CA*, Glidewell-Kenney C*, Jameson JL, Moenter SM (*equal contribution)
Endocrinology, 149:5328-5334


Vasoactive intestinal polypeptide can excite gonadotropin-releasing hormone neurons in a manner dependent on estradiol and gated by time of day
Christian CA, Moenter SM
Endocrinology, 149:3130-3136


2007
Estradiol induces diurnal shifts in GABA transmission to gonadotropin-releasing hormone neurons to provide a neural signal for ovulation
Christian CA, Moenter SM
J Neurosci, 27:1913-1921


2005
Diurnal and estradiol-dependent changes in gonadotropin-releasing hormone neuron firing activity
Christian CA, Mobley JL, Moenter SM
Proc Natl Acad Sci USA, 102:15682-15687


2002
Three days of novel wheel access diminishes light-induced phase delays in vivo with no effect on Per1 induction by light
Christian CA, Harrington ME
Chronobiol Int, 19:671-682