in press
Optoalpha1AR activation in astrocytes modulates basal hippocampal synaptic excitation and inhibition in a stimulation-specific manner
Courtney CD, Sobieski C, Ramakrishnan C, Ingram RJ, Wojnowski NM, DeFazio RA, Deisseroth K, Christian-Hinman CA
Hippocampus
Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low-dose kainic acid systemic injection paradigm in mice
Lawande NV, Conklin EA, Christian-Hinman CA
Epilepsia Open
Tumor suppressor p53 modulates activity-dependent synapse strengthening, autism-like behavior and hippocampus-dependent learning
Lee KY, Wang H, Yook Y, Rhodes JS, Christian-Hinman CA, Tsai NP
Mol Psychiatry
Genetic ablation of dentate hilar somatostatin-positive GABAergic interneurons is sufficient to induce cognitive impairment
Nagarajan R, Lyu J, Kambali M, Wang M, Courtney CD, Christian-Hinman CA, Rudolph U
Mol Neurobiol
2023
Mechanisms linking neurological disorders with reproductive endocrine dysfunction: Insights from epilepsy research
Cutia CA, Christian-Hinman CA
Front Neuroendocrinol, 71:101084
Sex and estrous cycle stage shape left-right asymmetry in chronic hippocampal seizures in mice
Cutia CA, Leverton LK, Christian-Hinman CA
eNeuro, 10:ENEURO.0041-23.2023
Female-specific pituitary gonadotrope dysregulation in mice with chronic focal epilepsy
Cutia CA, Leverton LK, Weis KE, Raetzman LT, Christian-Hinman CA
Exp Neurol, 364:114389
Hormone Changes in Epilepsy
Christian-Hinman CA, Harden CL
Chapter 76 in Epilepsy: A Comprehensive Textbook, 3rd Edition, Engel Jr. J. and Moshé S.L. (editors-in-chief), Wolters Kluwer Health
2022
Increased GABA transmission to GnRH neurons after intrahippocampal kainic acid injection in mice is sex-specific and associated with estrous cycle disruption
Ingram RJ, Leverton LK, Daniels VC, Li J, Christian-Hinman CA
Neurobiol Dis, 172:105822
Epilepsy-associated increase in gonadotropin-releasing hormone neuron firing in diestrous female mice is independent of chronic seizure burden severity
Li J, Christian-Hinman CA
Epilepsy Res, 184:106948
Phenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice
Cutia CA, Leverton LK, Ge X, Youssef R, Raetzman LT, Christian-Hinman CA
Exp Neurol, 355:114118
Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity
Walters JM, Kim EC, Zhang J, Jeong HG, Bajaj A, Baculis B, Tracy G, Ibrahim B, Christian-Hinman CA, Llano DA, Huesmann GR, Chung HJ
Epilepsia, 63:1211-1224
2021
Spontaneous seizure and memory loss in mice expressing an epileptic encephalopathy variant in the calmodulin-binding domain of Kv7.2
Kim EC, Zhang J, Tang AY, Bolton EC, Rhodes JS, Christian-Hinman CA, Chung HJ
Proc Natl Acad Sci USA, 118:e2021265118
From benzodiazepines to fatty acids: Revisiting the role of ACBP/DBI
Alquier T, Christian-Hinman CA, Alfonso J, Færgeman NJ
Trends Endocrinol Metab, 32:890-903
Infantile spasms-linked Nedd4-2 mediates hippocampal plasticity and learning via cofilin signaling
Lee KY, Zhu J, Cutia CA, Christian-Hinman CA, Rhodes JS, Tsai NP
EMBO Reports, 22:e52645
Is On-Demand Dynorphin Destined to Be in Demand to Decrease Seizures?
Christian-Hinman CA
Epilepsy Curr, 21:48-50
2020
Simultaneous two-photon activation and imaging of neural activity based on spectral-temporal modulation of supercontinuum light
Liu YZ, Renteria C, Courtney CD, Ibrahim B, You S, Chaney EJ, Barkalifa R, Iyer RR, Zurauskas M, Tu H, Llano DA, Christian-Hinman CA, Boppart SA
Neurophotonics, 7:045007
Seizure burden fluctuates with the female reproductive cycle in a mouse model of chronic temporal lobe epilepsy
Li J, Leverton LK, Naganatanahalli LM, Christian-Hinman CA
Exp Neurol, 334:113492
Assessin' the Vexin' Connexin Between Severity of Epilepsy and Hippocampal Gliosis
Courtney CD, Christian-Hinman C
Epilepsy Curr, 20:294-296
Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies
Christian CA, Reddy DS, Maguire J, Forcelli PA
Pharmacol Rev, 72:767-800
Nucleus-specific modulation of phasic and tonic inhibition by endogenous neurosteroidogenesis in the murine thalamus
Christian CA
Synapse, 74:e22144
Show Me the Meaning of Being Lonely (and Its Effects on Seizure Burden and Comorbidities)
Lozano L, Christian CA
Epilepsy Curr, 20:48-50
A Single Test to Study Social Behavior and Repetitive Self-Grooming in Mice
Lawande NV*, Ujjainwala AL*, Christian CA (*equal contribution)
Bio Protoc, 10:e3499
2019
Estrous Cycle Monitoring in Mice with Rapid Data Visualization and Analysis
Pantier LK*, Li J*, Christian CA (*equal contribution)
Bio Protoc, 9:e3354
Inhibition Gets a New KAR Smell
Courtney CD, Christian CA
Epilepsy Curr, 19:187-189
Differential impacts on multiple forms of spatial and contextual memory in diazepam binding inhibitor knockout mice
Ujjainwala AL*, Courtney CD*, Wojnowski NM, Rhodes JS, Christian CA (*equal contribution)
J Neurosci Res, 97:683-697
Changes in both neuron intrinsic properties and neurotransmission drive the increase in GnRH neuron firing rate during estradiol positive feedback
Adams CE, DeFazio RA, Christian CA, Milescu LS, Schnell S, Moenter SM
J Neurosci, 39:2091-2101
2018
Dynamic and sex-specific changes in gonadotropin-releasing hormone neuron activity and excitability in a mouse model of temporal lobe epilepsy
Li J, Robare JA, Gao L, Ghane MA, Flaws JA, Nelson ME, Christian CA
eNeuro, 5:ENEURO.0273-18.2018
Subregion-specific impacts of genetic loss of diazepam binding inhibitor on synaptic inhibition in the murine hippocampus
Courtney CD, Christian CA
Neuroscience, 388:128-138
Genetic loss of diazepam binding inhibitor in mice impairs social interest
Ujjainwala AL, Courtney CD, Rhoads SG, Rhodes JS, Christian CA
Genes Brain Behav, 17:e12442
The Perils of Generalizing About GABA in Seizure Generalization
Christian CA
Epilepsy Curr, 18:113-114
Persistent Protection Against Pathology and Paroxysms by P2X7R Antagonism
Christian CA
Epilepsy Curr, 18:42-44
2017
Developmental Inflammation Takes a Toll: Early Immune Responses Increase Seizure Susceptibility via Astrocytic TLR4 Signaling
Sobieski C, Christian CA
Epilepsy Curr, 17:370-371
Mom Genes: A Role for Loss of Maternal Ube3a in GABAergic Neurons in Angelman Syndrome
Christian CA
Epilepsy Curr, 17:237-238
Regulation of thalamic and cortical network synchrony by Scn8a
Makinson CD, Tanaka BS, Sorokin JM, Wong JC, Christian CA, Goldin AL, Escayg A, Huguenard JR
Neuron, 93:1165-1179
Disrupted female estrous cyclicity in the intrahippocampal kainic acid mouse model of temporal lobe epilepsy
Li J, Kim JS, Abejuela VA, Lamano JB, Klein NJ, Christian CA
Epilepsia Open, 2:39-47
Neurophysiology of Gonadotropin-Releasing Hormone Neurons
Christian CA
In Hormones, Brain and Behavior, 3rd Edition, Pfaff, D.W. and Joëls, M. (editors-in-chief), Oxford: Academic Press. Vol. 3, pp. 379-400
2016
A Nose for Seizures: A Potential Role for Olfaction in the Co-Morbidity of Depression and Epilepsy?
Christian CA
Epilepsy Curr, 16:256-257
Seizure Activity and Intervention Efficacy are Shaped by REMnants of Preceding Brain States
Christian CA
Epilepsy Curr, 16:164-165
Feedback modulation of neural network synchrony and seizure susceptibility by Mdm2-p53-Nedd4-2 signaling
Jewett KA, Christian CA, Bacos JT, Lee KY, Zhu J, Tsai NP
Mol Brain, 9:32
2013
Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling
Christian CA, Huguenard JR
Proc Natl Acad Sci USA, 110:20278-20283
Sniffer Patch Laser Uncaging REsponse (SPLURgE): an assay of regional differences in allosteric receptor modulation and neurotransmitter clearance
Christian CA, Huguenard JR
J Neurophysiol, 110:1722-1731
Endogenous positive allosteric modulation of GABA(A) receptors by Diazepam binding inhibitor
Christian CA, Herbert AG, Holt RL, Peng K, Sherwood KD, Pangratz-Fuehrer S, Rudolph U, Huguenard JR
Neuron, 78:1063-1074
2010
Focal cortical infarcts alter intrinsic excitability and synaptic excitation in the reticular thalamic nucleus
Paz JT, Christian CA, Parada I, Prince DA, Huguenard JR
J Neurosci, 30:5465-5479
The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges
Christian CA, Moenter SM
Endocr Rev, 31:544-577
2009
Neurobiological mechanisms underlying oestradiol negative and positive feedback regulation of gonadotrophin-releasing hormone neurones
Moenter SM, Chu Z, Christian CA
J Neuroendocrinol, 21:327-333
Estradiol suppresses glutamatergic transmission to gonadotropin-releasing hormone neurons in a model of negative feedback in mice
Christian CA, Pielecka-Fortuna J, Moenter SM
Biol Reprod, 80:1128-1135
2008
Critical roles for fast synaptic transmission in mediating estradiol negative and positive feedback in the neural control of ovulation
Christian CA, Moenter SM
Endocrinology, 149:5500-5508
Classical estrogen receptor alpha signaling mediates negative and positive feedback on gonadotropin-releasing hormone neuron firing
Christian CA*, Glidewell-Kenney C*, Jameson JL, Moenter SM (*equal contribution)
Endocrinology, 149:5328-5334
Vasoactive intestinal polypeptide can excite gonadotropin-releasing hormone neurons in a manner dependent on estradiol and gated by time of day
Christian CA, Moenter SM
Endocrinology, 149:3130-3136
2007
Estradiol induces diurnal shifts in GABA transmission to gonadotropin-releasing hormone neurons to provide a neural signal for ovulation
Christian CA, Moenter SM
J Neurosci, 27:1913-1921
2005
Diurnal and estradiol-dependent changes in gonadotropin-releasing hormone neuron firing activity
Christian CA, Mobley JL, Moenter SM
Proc Natl Acad Sci USA, 102:15682-15687
2002
Three days of novel wheel access diminishes light-induced phase delays in vivo with no effect on Per1 induction by light
Christian CA, Harrington ME
Chronobiol Int, 19:671-682
Optoalpha1AR activation in astrocytes modulates basal hippocampal synaptic excitation and inhibition in a stimulation-specific manner
Courtney CD, Sobieski C, Ramakrishnan C, Ingram RJ, Wojnowski NM, DeFazio RA, Deisseroth K, Christian-Hinman CA
Hippocampus
Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low-dose kainic acid systemic injection paradigm in mice
Lawande NV, Conklin EA, Christian-Hinman CA
Epilepsia Open
Tumor suppressor p53 modulates activity-dependent synapse strengthening, autism-like behavior and hippocampus-dependent learning
Lee KY, Wang H, Yook Y, Rhodes JS, Christian-Hinman CA, Tsai NP
Mol Psychiatry
Genetic ablation of dentate hilar somatostatin-positive GABAergic interneurons is sufficient to induce cognitive impairment
Nagarajan R, Lyu J, Kambali M, Wang M, Courtney CD, Christian-Hinman CA, Rudolph U
Mol Neurobiol
2023
Mechanisms linking neurological disorders with reproductive endocrine dysfunction: Insights from epilepsy research
Cutia CA, Christian-Hinman CA
Front Neuroendocrinol, 71:101084
Sex and estrous cycle stage shape left-right asymmetry in chronic hippocampal seizures in mice
Cutia CA, Leverton LK, Christian-Hinman CA
eNeuro, 10:ENEURO.0041-23.2023
Female-specific pituitary gonadotrope dysregulation in mice with chronic focal epilepsy
Cutia CA, Leverton LK, Weis KE, Raetzman LT, Christian-Hinman CA
Exp Neurol, 364:114389
Hormone Changes in Epilepsy
Christian-Hinman CA, Harden CL
Chapter 76 in Epilepsy: A Comprehensive Textbook, 3rd Edition, Engel Jr. J. and Moshé S.L. (editors-in-chief), Wolters Kluwer Health
2022
Increased GABA transmission to GnRH neurons after intrahippocampal kainic acid injection in mice is sex-specific and associated with estrous cycle disruption
Ingram RJ, Leverton LK, Daniels VC, Li J, Christian-Hinman CA
Neurobiol Dis, 172:105822
Epilepsy-associated increase in gonadotropin-releasing hormone neuron firing in diestrous female mice is independent of chronic seizure burden severity
Li J, Christian-Hinman CA
Epilepsy Res, 184:106948
Phenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice
Cutia CA, Leverton LK, Ge X, Youssef R, Raetzman LT, Christian-Hinman CA
Exp Neurol, 355:114118
Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity
Walters JM, Kim EC, Zhang J, Jeong HG, Bajaj A, Baculis B, Tracy G, Ibrahim B, Christian-Hinman CA, Llano DA, Huesmann GR, Chung HJ
Epilepsia, 63:1211-1224
2021
Spontaneous seizure and memory loss in mice expressing an epileptic encephalopathy variant in the calmodulin-binding domain of Kv7.2
Kim EC, Zhang J, Tang AY, Bolton EC, Rhodes JS, Christian-Hinman CA, Chung HJ
Proc Natl Acad Sci USA, 118:e2021265118
From benzodiazepines to fatty acids: Revisiting the role of ACBP/DBI
Alquier T, Christian-Hinman CA, Alfonso J, Færgeman NJ
Trends Endocrinol Metab, 32:890-903
Infantile spasms-linked Nedd4-2 mediates hippocampal plasticity and learning via cofilin signaling
Lee KY, Zhu J, Cutia CA, Christian-Hinman CA, Rhodes JS, Tsai NP
EMBO Reports, 22:e52645
Is On-Demand Dynorphin Destined to Be in Demand to Decrease Seizures?
Christian-Hinman CA
Epilepsy Curr, 21:48-50
2020
Simultaneous two-photon activation and imaging of neural activity based on spectral-temporal modulation of supercontinuum light
Liu YZ, Renteria C, Courtney CD, Ibrahim B, You S, Chaney EJ, Barkalifa R, Iyer RR, Zurauskas M, Tu H, Llano DA, Christian-Hinman CA, Boppart SA
Neurophotonics, 7:045007
Seizure burden fluctuates with the female reproductive cycle in a mouse model of chronic temporal lobe epilepsy
Li J, Leverton LK, Naganatanahalli LM, Christian-Hinman CA
Exp Neurol, 334:113492
Assessin' the Vexin' Connexin Between Severity of Epilepsy and Hippocampal Gliosis
Courtney CD, Christian-Hinman C
Epilepsy Curr, 20:294-296
Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies
Christian CA, Reddy DS, Maguire J, Forcelli PA
Pharmacol Rev, 72:767-800
Nucleus-specific modulation of phasic and tonic inhibition by endogenous neurosteroidogenesis in the murine thalamus
Christian CA
Synapse, 74:e22144
Show Me the Meaning of Being Lonely (and Its Effects on Seizure Burden and Comorbidities)
Lozano L, Christian CA
Epilepsy Curr, 20:48-50
A Single Test to Study Social Behavior and Repetitive Self-Grooming in Mice
Lawande NV*, Ujjainwala AL*, Christian CA (*equal contribution)
Bio Protoc, 10:e3499
2019
Estrous Cycle Monitoring in Mice with Rapid Data Visualization and Analysis
Pantier LK*, Li J*, Christian CA (*equal contribution)
Bio Protoc, 9:e3354
Inhibition Gets a New KAR Smell
Courtney CD, Christian CA
Epilepsy Curr, 19:187-189
Differential impacts on multiple forms of spatial and contextual memory in diazepam binding inhibitor knockout mice
Ujjainwala AL*, Courtney CD*, Wojnowski NM, Rhodes JS, Christian CA (*equal contribution)
J Neurosci Res, 97:683-697
Changes in both neuron intrinsic properties and neurotransmission drive the increase in GnRH neuron firing rate during estradiol positive feedback
Adams CE, DeFazio RA, Christian CA, Milescu LS, Schnell S, Moenter SM
J Neurosci, 39:2091-2101
2018
Dynamic and sex-specific changes in gonadotropin-releasing hormone neuron activity and excitability in a mouse model of temporal lobe epilepsy
Li J, Robare JA, Gao L, Ghane MA, Flaws JA, Nelson ME, Christian CA
eNeuro, 5:ENEURO.0273-18.2018
Subregion-specific impacts of genetic loss of diazepam binding inhibitor on synaptic inhibition in the murine hippocampus
Courtney CD, Christian CA
Neuroscience, 388:128-138
Genetic loss of diazepam binding inhibitor in mice impairs social interest
Ujjainwala AL, Courtney CD, Rhoads SG, Rhodes JS, Christian CA
Genes Brain Behav, 17:e12442
The Perils of Generalizing About GABA in Seizure Generalization
Christian CA
Epilepsy Curr, 18:113-114
Persistent Protection Against Pathology and Paroxysms by P2X7R Antagonism
Christian CA
Epilepsy Curr, 18:42-44
2017
Developmental Inflammation Takes a Toll: Early Immune Responses Increase Seizure Susceptibility via Astrocytic TLR4 Signaling
Sobieski C, Christian CA
Epilepsy Curr, 17:370-371
Mom Genes: A Role for Loss of Maternal Ube3a in GABAergic Neurons in Angelman Syndrome
Christian CA
Epilepsy Curr, 17:237-238
Regulation of thalamic and cortical network synchrony by Scn8a
Makinson CD, Tanaka BS, Sorokin JM, Wong JC, Christian CA, Goldin AL, Escayg A, Huguenard JR
Neuron, 93:1165-1179
Disrupted female estrous cyclicity in the intrahippocampal kainic acid mouse model of temporal lobe epilepsy
Li J, Kim JS, Abejuela VA, Lamano JB, Klein NJ, Christian CA
Epilepsia Open, 2:39-47
Neurophysiology of Gonadotropin-Releasing Hormone Neurons
Christian CA
In Hormones, Brain and Behavior, 3rd Edition, Pfaff, D.W. and Joëls, M. (editors-in-chief), Oxford: Academic Press. Vol. 3, pp. 379-400
2016
A Nose for Seizures: A Potential Role for Olfaction in the Co-Morbidity of Depression and Epilepsy?
Christian CA
Epilepsy Curr, 16:256-257
Seizure Activity and Intervention Efficacy are Shaped by REMnants of Preceding Brain States
Christian CA
Epilepsy Curr, 16:164-165
Feedback modulation of neural network synchrony and seizure susceptibility by Mdm2-p53-Nedd4-2 signaling
Jewett KA, Christian CA, Bacos JT, Lee KY, Zhu J, Tsai NP
Mol Brain, 9:32
2013
Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling
Christian CA, Huguenard JR
Proc Natl Acad Sci USA, 110:20278-20283
Sniffer Patch Laser Uncaging REsponse (SPLURgE): an assay of regional differences in allosteric receptor modulation and neurotransmitter clearance
Christian CA, Huguenard JR
J Neurophysiol, 110:1722-1731
Endogenous positive allosteric modulation of GABA(A) receptors by Diazepam binding inhibitor
Christian CA, Herbert AG, Holt RL, Peng K, Sherwood KD, Pangratz-Fuehrer S, Rudolph U, Huguenard JR
Neuron, 78:1063-1074
2010
Focal cortical infarcts alter intrinsic excitability and synaptic excitation in the reticular thalamic nucleus
Paz JT, Christian CA, Parada I, Prince DA, Huguenard JR
J Neurosci, 30:5465-5479
The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges
Christian CA, Moenter SM
Endocr Rev, 31:544-577
2009
Neurobiological mechanisms underlying oestradiol negative and positive feedback regulation of gonadotrophin-releasing hormone neurones
Moenter SM, Chu Z, Christian CA
J Neuroendocrinol, 21:327-333
Estradiol suppresses glutamatergic transmission to gonadotropin-releasing hormone neurons in a model of negative feedback in mice
Christian CA, Pielecka-Fortuna J, Moenter SM
Biol Reprod, 80:1128-1135
2008
Critical roles for fast synaptic transmission in mediating estradiol negative and positive feedback in the neural control of ovulation
Christian CA, Moenter SM
Endocrinology, 149:5500-5508
Classical estrogen receptor alpha signaling mediates negative and positive feedback on gonadotropin-releasing hormone neuron firing
Christian CA*, Glidewell-Kenney C*, Jameson JL, Moenter SM (*equal contribution)
Endocrinology, 149:5328-5334
Vasoactive intestinal polypeptide can excite gonadotropin-releasing hormone neurons in a manner dependent on estradiol and gated by time of day
Christian CA, Moenter SM
Endocrinology, 149:3130-3136
2007
Estradiol induces diurnal shifts in GABA transmission to gonadotropin-releasing hormone neurons to provide a neural signal for ovulation
Christian CA, Moenter SM
J Neurosci, 27:1913-1921
2005
Diurnal and estradiol-dependent changes in gonadotropin-releasing hormone neuron firing activity
Christian CA, Mobley JL, Moenter SM
Proc Natl Acad Sci USA, 102:15682-15687
2002
Three days of novel wheel access diminishes light-induced phase delays in vivo with no effect on Per1 induction by light
Christian CA, Harrington ME
Chronobiol Int, 19:671-682